TOR DE FRANCE

Target Of Rapamycin
science club in France

- 4th edition -

9-10 October 2025
Saint Paul Hôtel, Nice, France

Target Of Rapamycin (TOR) pathway has an evolutionary conserved role in the control of growth, metabolism, stress response, survival and ageing.

Currently "TOR de France" is a unique conference series in the world entirely devoted to field of "Target Of Rapamycin" signaling, nutrition, growth, metabolism, development. The "TOR de France" meeting gathers students, postdocs, research group leaders and medical doctors working on various aspects of TOR biology and the applications in medicine, pharmacology, human health. This pluridiplinary approach allows new and fruitful feedbacks on everyone's work and have proven to foster innovative collaborations.


After the success of the first editions in 2018, 2021 and 2023, the TOR de France has now a strong and growing international community. We are looking forward to meeting you for the fourth edition! Please visit the site in the spring 2024 for the program and registration.

TOR de France 2023

Special edition
50th anniversary of the discovery of Rapamycin

Abstract submission deadline: sept. 10th


Booklet

Download poster▼

Group ToR 2023

Preliminary program
Thursday 9 of October, 2025
09:30-10:30
Arrival and registration
10:30-10:45
Welcome and introduction
Members of organizing committee
50 years of Rapamycin discovery
10:45-11:00
From Rapa Nui to Rapamycin
Svetlana Dokudovskaya
IGR, Villejuif, France
mTOR AND METABOLISM
11:00-11:30
Michael Hall
mTOR signaling in growth, metabolism and disease
11:30-12:00
Wilhelm Palm
mTORC1 controls endo-lysosomal nutrient acquisition
12:00-12:15
Fried Zwartkruis
mTORC1 controls amino acid homeostasis via glutamine metabolism
12:15-12:30
Nesli Ece Sen Arsovic
TORC2 is acutely regulated by glucose availability
12:30-13:00
Nicolas Dupont
Role of mTOR and autophagy in mechanotransduction to control renal cell homeostasis
Lunch
MOLECULAR MECHANISMS OF mTOR REGULATION
14:15-15:00
Keynote lecture
Spatial Separation of Nutrient Signaling to mTORC1
Constantinos Demetriades
MPI-AGE, Germany
15:00-15:15
Riko Hatakeyama
Spatially and functionally distinct TORC1 pools in yeast and beyond: Concept, approach, and implications
15:15-15:30
Wim Annaert
VPS13C interaction with GATOR2 is required for mTORC1 activation in plasma membrane-endoplasmic reticulum contact sites
15:30-15:45
Stephanie Fernandes
The tumor suppressor CYLD acts as a deubiquitinase for mTOR to constrain its activity
15:45-16:15
Bernadette Carroll
mTORC1 signalling in cellular senescence and ageing
Coffee break
16:45-17:15
David Sabatini
Nutrient sensing by the mTORC1 pathway
17:15-17:45
Matthias Gehringer
Discovery of Highly Potent and Selective S6K2 Inhibitors
17:45-18:20
Flash Talks students
Shiwani Kumari, Alessia Perciavalle, Vonda Koka, Jiyoung Pan, Samuel Laurent, Giorgia Piccoli, Ann-Sofie De Meulemeester
18:20-19:30
Poster session
19:30
Cocktail
Friday 10 of October, 2025
NEUROBIOLOGY AND BRAIN DISORDERS
09:30-10:15
Keynote lecture
Dietary protein and appetite control: is it all about mTOR ?
Clémence Blouet
University of Cambridge, UK
10:15-10:45
Andrea Ballabio
mTORC1 substrate-specificity in cancer
10:45-11:00
Mike Fainzilber
Stretching to Grow - Locally Translated mTOR Controls Interstitial Axonal Elongation
Coffee break
11:30-12:15
Keynote lecture
Dissecting the role of mTOR complexes in epilepsy
Mauro Costa-Mattioli
Memory and Brain Research Center at Baylor College of Medicine
12:15-12:30
Paul Dutchak
ASO Therapeutics Targeting mTORC1-dependent Epilespy
12:30-12:45
Joseph Bateman
Phosphoproteomics identifies RNA-metabolism defects in the brain in TSC
12:45-13:00
Flash talks PI
Dorota Ciołczyk-Wierzbicka, Julian Martinez-Agosto, Jacek Jaworski, Andrea Oeckinghaus
Lunch
TUBEROUS SCLEROSIS COMPLEX
14:15-15:00
Keynote lecture
Novel Disease Mechanisms in Tuberous Sclerosis Complex
Lisa Henske
MIT - Harvard, USA
15:00-15:30
Anna Jansen
Closing the Care Gap: Advancing Neuropsychiatric Research in Tuberous Sclerosis Complex Through Global Collaboration and Digital Innovation
15:30-15:45
Floor Jansen
Challenges in identifying relevant subependymal lesions in children with tuberous sclerosis complex
15:45-16:00
Justyna Zmorzynska
Rac1 contributions to TSC-associated Neuropsychiatric Disorders
16:00-16:15
Salvatore Gagliotta
TFEB drives renal pathology in Tuberous Sclerosis Complex human kidney organoids
Coffee break
GROWTH & DISEASE
16:45-17:00
Mojgan Djavaheri-Mergny
The antidepressants sertraline and indatraline induce TFEB activation and immunogenic cell death
17:00-17:15
Viktor Korolchuk
Role of mTOR in cellular ageing phenotypes
17:15-17:30
Matthias Wymann
Non-redundant functions of PI3Kγ complexes in obesity and metaflammation
17:30-17:45
Alejo Efeyan
Cell-intrinsic and paracrine Rag GTPase signaling in cancer
17:45-18:15
Andrei Chagin
mTORC1 signaling links maternal diet to craniofacial morphogenesis
18:15-18:30
Awards and closing
19:30
Gala dinner in Nice center

Scientific Committee
photo Ballabio
Andrea Ballabio
Tigem, Naples, Italy
photo Canaud
Guillaume Canaud
Necker Institute, Paris, France
photo de Virgilio
Claudio de Virgilio
University of Fribourg, Switzerland
photo Dengjel
Jörn Dengjel
University of Fribourg, Fribourg, Switzerland
photo Efeyan
Alejo Efeyan
CNIO, Madrid, Spain
photo Fafournoux
Pierre Fafournoux
INRA, Clermont Ferrand, France
photo Gehringer
Matthias Gehringer
University of Tübingen, Tübingen, Germany
photo Gkogkas
Christos Gkogkas
Forth-BRI, Ioannina, Greece
photo Jansen
Floor Jansen
UMC Utrecht, Utrecht, the Netherlands
photo Marçais
Antoine Marçais
CIRI, Lyon, France
photo Mekahli
Djalila Mekahli
KU Leuven, Leuven, Belgium
photo Meyer
Christian Meyer
Bourgin Inst., Paris, France
photo Thedieck
Kathrin Thedieck
Research Center One Health Ruhr, Essen, Germany
photo Walzer
Thierry Walzer
CIRI, Lyon, France
photo Wymann
Matthias Wymann
University of Basel, Basel, Switzerland
photo Zmorzynska
Justyna Zmorzynska
Imol PAS, Warsaw, Poland

Scientific Organizers
photo Baulac
Stéphanie Baulac
ICM, Paris, France
photo Dokudovskaya
Svetlana Dokudovskaya
IGR, Villejuif, France
photo Pende
Mario Pende
Necker Institute, Paris, France
photo Schramm
Adrien Schramm
Executive Organizer

Le Saint Paul Hotel

29 boulevard Franck Pilatte
06300 Nice
France - Europe
reservation@lesaintpaul-hotel.com
+33 (0)4 93 89 39 57
www.lesaintpaul-hotel.com
The Saint Paul hotel is nearly full!
Alternatively, there are several options nearby (Ibis Styles vieux port, Hotel le G, Agata Hotel...)

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